Hydrochloric Acid → (2-{4-[(2R)-2-Amino-3-(4-chlorophenyl)propanoyl]-piperazinyl}phenyl)-N,N-dimethylcarboxamide HCl salt

HRID 1242763Notes

Reaction equation

HRID 1242763 reaction equation
C(OC([NH:8][C@H:9]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]([N:26]([CH3:28])[CH3:27])=[O:25])[CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.Cl>CCOC(C)=O>[ClH:36].[NH2:8][C@H:9]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)[C:10]([N:12]1[CH2:13][CH2:14][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]([N:26]([CH3:28])[CH3:27])=[O:25])[CH2:16][CH2:17]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69071519[2-(4-{(2R)-2-[(tert-Butoxy)carbonylamino]-3-(4-chlorophenyl)propanoyl}piperazinyl)phenyl]-N,N-dimethylcarboxamide

Product 1

HCID 69075714(2-{4-[(2R)-2-Amino-3-(4-chlorophenyl)propanoyl]-piperazinyl}phenyl)-N,N-dimethylcarboxamide HCl salt

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(2-{4-[(2R)-2-Amino-3-(4-chlorophenyl)propanoyl]-piperazinyl}phenyl)-N,N-dimethylcarboxamide HCl salt was prepared according to the procedure described in Preparation XVI by using [2-(4-{(2R)-2-[(tert-butoxy)carbonylamino]-3-(4-chlorophenyl)propanoyl}-piperazinyl)phenyl]-N,N-dimethylcarboxamide (Step 4) (240 mg, 0.46 mmol) and a satd soln of HCl in EtOAc (10 mL). The white solid that formed was isolated by filtration (200 mg). MS (ESI, pos.ion) m/z: 415 (M+H). Calc'd for C22H28Cl2N4O2: 451.39.

Workup

  1. customThe white solid that formed
  2. customwas isolated by filtration (200 mg)

Sources & evidence

ORD record
ord-8096168c647a4c9ca78624ef28cac14c
Source dataset
uspto-grants-2006_10
Patent number
US07115607B2

Reaction notes

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