Dimethylformamide dimethyl acetal → HCID 21939863, compound

HRID 1242900Notes

Reaction equation

HRID 1242900 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[C:9]([NH:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[C:18](=[O:22])[CH2:17][CH2:16]2)(=[O:11])[CH3:10]>>[CH3:3][N:4](/[CH:6]=[C:17]1/[C:18](=[O:22])[C:19]2[C:15]([CH2:16]/1)=[CH:14][C:13]([NH:12][C:9](=[O:11])[CH3:10])=[CH:21][CH:20]=2)[CH3:5]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 312894N-(1-Oxo-2,3-dihydro-1H-inden-5-yl)acetamide

Product 1

HCID 21939863HCID 21939863, compound

Conditions

Temperature
100 °C

Procedure

Dimethylformamide dimethylacetal was added to 5-acetamido-1-indanone (2.5 g, 13.2 mmol), which was stirred at 100° C. for 3.5 hours, and cooled to room temperature. The precipitated crude products were collected, which was washed with ethyl acetate to give the titled compound (2.73 g).

Workup

  1. temperaturecooled to room temperature
  2. customThe precipitated crude products
  3. customwere collected
  4. washwhich was washed with ethyl acetate

Sources & evidence

ORD record
ord-8e459ffcea8549cabb7946ba3da3ae7f
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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