反应详情

温度

110 °C

A test tube was charged with CuI (20 mg, 0.10 mmol, 10 mol %), 5-methyl-1,10-phenanthroline (39 mg, 0.20 mmol, 20 mol %), Cs2CO3 (652 mg, 2.0 mmol), 4-iodoanisole (234 mg, 1.0 mmol) and cyclopentanol (1.0 mL). The test tube was sealed and the reaction mixture was stirred at 110° C. for 24 h. The resulting suspension was cooled to room temperature and filtered through a 0.5×1 cm pad of silica gel eluting with diethyl ether. The filtrate was concentrated. Purification of the residue by flash chromatography on silica gel (2×20 cm; pentane/diethyl ether 30:1) provided 128 mg (67% yield) of the title compound as a colorless oil.

1. customThe test tube was sealed
2. temperatureThe resulting suspension was cooled to room temperature
3. filtrationfiltered through a 0.5×1 cm pad of silica gel eluting with diethyl ether
4. concentrationThe filtrate was concentrated
5. customPurification of the residue by flash chromatography on silica gel (2×20 cm; pentane/diethyl ether 30:1)