反应详情

The carbamate from Example 33D (1.5 g, 4.3 mmol) was dissolved in DMF (4.0 mL) followed by addition of MeI (1.1 g, 8.0 mmol) and NaH (50%, 384 mg, 8.0 mmol) at 0° C. The mixture was stirred for 6 hours, diluted with aqueous NH4Cl and extracted with ethyl acetate(3×75 mL). The combined organic layers were dried with MgSO4, filtered, concentrated under reduced pressure to provide the titled compound (1.3 g, 83%).

1. extractionextracted with ethyl acetate(3×75 mL)
2. dry with materialThe combined organic layers were dried with MgSO4
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure