Pyridine → Tert-butyl 4-((benzyloxycarbonylamino)methyl)-4-(3-(dimethylcarbamoyloxy)phenylcarbamoyl)piperidine-1-carboxylate

HRID 124330Notes

Reaction equation

HRID 124330 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[NH:11][CH2:12][C:13]1([C:26](=[O:27])[OH:28])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1.[CH3:41][N:42]([C:43]([O:44][c:45]1[cH:46][c:47]([NH2:51])[cH:48][cH:49][cH:50]1)=[O:52])[CH3:53].[Cl:35][C:36]([C:37]([Cl:38])=[O:39])=[O:40].[Cl:54][CH2:55][Cl:56].[O:57]=[CH:58][N:59]([CH3:60])[CH3:61].[cH:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[NH:11][CH2:12][C:13]1([C:26](=[O:27])[NH:51][c:47]2[cH:46][c:45]([O:44][C:43]([N:42]([CH3:41])[CH3:53])=[O:52])[cH:50][cH:49][cH:48]2)[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1

Participants

7

Reactant 6

HCID 1049PyridineHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 298773-Aminophenyl dimethylcarbamateHCID 65578Oxalyl chlorideHCID 670368724-({[(Benzyloxy)carbonyl]amino}methyl)-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Product 1

HCID 68991379Tert-butyl 4-((benzyloxycarbonylamino)methyl)-4-(3-(dimethylcarbamoyloxy)phenylcarbamoyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3a62580b78b4421a8d257242ee58e873
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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