Ethylene Glycol → HCID 21925647, compound

Temperature

80 °C

Sodium hydride (125 mg, 60% dispersion in mineral oil, 3.13 mmol) was added to a mixture of 4-chloro-2-fluoronitrobenzene (500 mg, 2.85 mmol) and ethylene glycol (0.18 ml, 3.13 mmol) in 1-methyl-2-pyrrolidinone (5 ml) and the reaction stirred at 80° C. for 18 hours. TLC analysis showed starting material remaining, so additional sodium hydride (114 mg, 60% dispersion in mineral oil, 2.85 mmol) and ethylene glycol (0.82 ml, 14.25 mmol) were added and the reaction stirred at 110° C. for a further 18 hours. The cooled mixture was partitioned between water and dichloromethane, and the layers separated. The organic phase was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using ethyl acetate:pentane (50:50) as eluant to afford the title compound as a solid, 290 mg.

1. stirringthe reaction stirred at 110° C. for a further 18 hours
2. customThe cooled mixture was partitioned between water and dichloromethane
3. customthe layers separated
4. dry with materialThe organic phase was dried over magnesium sulphate
5. customevaporated under reduced pressure
6. customThe residue was purified by column chromatography on silica gel

ORD record

ord-77748b853bfe4edc8d281f61d0f6fda1

Source dataset

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07119088B2