反应详情

温度

95 °C

A mixture of the amine from example 4 (500 mg, 1.3 mmol), potassium carbonate (480 mg, 3.5 mmol) and 4-chloropyrimidine (300 mg, 2.6 mmol) was stirred at 95° C. for 18 hours. The cooled reaction mixture was diluted with ethyl acetate and the solution was washed with brine (5×), then dried over magnesium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel using dichloromethane:methanol (100:0 to 95:5) as eluant, and the product was triturated with diethyl ether to afford the title compound (80 mg).

1. customThe cooled reaction mixture
2. washthe solution was washed with brine (5×)
3. dry with materialdried over magnesium sulphate
4. concentrationconcentrated under reduced pressure
5. customThe crude product was purified by column chromatography on silica gel
6. customthe product was triturated with diethyl ether