Hydrochloric Acid → 2-[1-Ethyl-3-(methylamino)propoxy]-6-(trifluoromethyl)-3-pyridinecarbonitrile hydrochloride

HRID 1243609Notes

Reaction equation

HRID 1243609 reaction equation
[C:1]([C:3]1[C:4]([O:13][CH:14]([CH2:26][CH3:27])[CH2:15][CH2:16][N:17](C)[C:18](=O)OC(C)(C)C)=[N:5][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:8]=1)#[N:2].[ClH:28]>O1CCOCC1>[ClH:28].[CH2:26]([CH:14]([O:13][C:4]1[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[C:6]([C:9]([F:12])([F:10])[F:11])[N:5]=1)[CH2:15][CH2:16][NH:17][CH3:18])[CH3:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 696559231,1-Dimethylethyl [3-[[3-cyano-6-(trifluoromethyl)-2-pyridinyl]oxy]pentyl]methylcarbamate

Product 1

HCID 219283592-[1-Ethyl-3-(methylamino)propoxy]-6-(trifluoromethyl)-3-pyridinecarbonitrile hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl [3-[[3-cyano-6-(trifluoromethyl)-2-pyridinyl]oxy]pentyl]methylcarbamate (170 mg) was dissolved in 4M HCl in dioxane (10 ml). The resulting solution was stirred at room temperature for 2 h, then the solvent was evaporated. The residue was recrystallised from diethyl ether/ethanol to give the title compound (100 mg) as a white solid.

Workup

  1. customthe solvent was evaporated
  2. customThe residue was recrystallised from diethyl ether/ethanol

Sources & evidence

ORD record
ord-c13c3f2294f74c538fd20619a6744d2a
Source dataset
uspto-grants-2006_10
Patent number
US07119109B2

Reaction notes

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