Sodium Hydroxide → HCID 21930688, compound

HRID 1243774Notes

Reaction equation

HRID 1243774 reaction equation
[C:1]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])(=[O:6])[CH2:2][C:3]([O-:5])=[O:4].[OH-].[Na+].[C:14]12([C:24]([CH2:26]Br)=[O:25])[CH2:23][CH:18]3[CH2:19][CH:20]([CH2:22][CH:16]([CH2:17]3)[CH2:15]1)[CH2:21]2>C1COCC1>[C:14]12([C:24]([CH2:26][CH:2]([C:3]([O:5][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:4])[C:1]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])=[O:25])[CH2:23][CH:18]3[CH2:19][CH:20]([CH2:22][CH:16]([CH2:17]3)[CH2:15]1)[CH2:21]2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 197820Bromomethyl tricyclo[3.3.1.13,7]dec-1-yl ketoneHCID 21883978Tert-butyl malonate

Product 1

HCID 21930688HCID 21930688, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To tert-butyl malonate was added, in THF, an equimolar amount of sodium hydroxide. To this mixture was added bromomethyl adamantyl ketone, and the mixture was stirred for 3 hours. The salt precipitated was filtered off, and the filtrate was concentrated to obtain di-tert-butyl 2-((1-adamantyl)carbonyl-methyl)malonate (ADTB).

Workup

  1. customThe salt precipitated
  2. filtrationwas filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f7eb8a2e89c94ce78b1a56b03ea86aad
Source dataset
uspto-grants-2006_10
Patent number
US07119156B2

Reaction notes

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