Hydrochloric Acid → HCID 14819311, compound

HRID 1243777Notes

Reaction equation

HRID 1243777 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]([C:11]1[S:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[CH:12]=1)=[O:10])(C)(C)C.CCOC(C)=O.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:7][CH2:8][C:9]([C:11]1[S:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[CH:12]=1)=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 21064726HCID 21064726, compound

Product 1

HCID 14819311HCID 14819311, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(2-Benzo[b]thiophen-2-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (544 mg, 1.867 mmol) was dissolved into 3 mL of EtOAc and 10 mL of 4.0 M HCl in dioxane was added. The mixture was allowed to stir overnight with a white precipitate forming. The precipitate was triturated with 3×10 mL of EtOAc and dried under vacuum to give 400 mg, 94.7% of crude 2-amino-1-benzo[b]thiophen-2-yl-ethanone HCl salt. The material was carried on without further purification.

Workup

  1. additionwas added
  2. customforming
  3. customThe precipitate was triturated with 3×10 mL of EtOAc
  4. customdried under vacuum

Sources & evidence

ORD record
ord-a4acd6ba0e48408889d0bc7ae7e5100e
Source dataset
uspto-grants-2006_10
Patent number
US07119102B2

Reaction notes

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