Triethylamine → HCID 12962619, compound

HRID 1243779Notes

Reaction equation

HRID 1243779 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]=[O:7])=[CH:2]1.[CH3:8][Si:9](C#N)([CH3:11])[CH3:10].[CH2:14]([N:16](CC)CC)C>C(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([CH:6]([O:7][Si:9]([CH3:11])([CH3:10])[CH3:8])[C:14]#[N:16])=[CH:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 681353-ThiophenecarboxaldehydeHCID 82115Trimethylsilyl cyanide

Product 1

HCID 12962619HCID 12962619, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Thiophene carboxaldehyde (0.438 mL, 5.000 mmol) was dissolved into dry CH2Cl2 and placed under argon. To this was added trimethylsilyl cyanide (0.933 mL, 7.000 mmol) and triethylamine (0.070 mL, 0.500 mmol). The reaction mixture was allowed to stir for 4 h. The mixture was concentrated on a rotary evaporator to dryness to give thiophen-3-yl-trimethylsilanyloxy-acetonitrile as a clear oil.

Workup

  1. concentrationThe mixture was concentrated on a rotary evaporator to dryness

Sources & evidence

ORD record
ord-39ab95e08fd444e48ac040bfb6de25fd
Source dataset
uspto-grants-2006_10
Patent number
US07119102B2

Reaction notes

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