Hydrochloric Acid → HCID 21928083, compound

HRID 1243783Notes

Reaction equation

HRID 1243783 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][N:12]=1)[OH:10])(C)(C)C.[ClH:28].O1CCOCC1>CCOC(C)=O>[ClH:28].[ClH:28].[NH2:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:26])=[CH:13][N:12]=1)[OH:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21064723HCID 21064723, compound

Product 1

HCID 21928083HCID 21928083, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[2-(5-Benzylcarbamoyl-pyridin-2-yl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (47.0 mg, 0.129 mmol) was dissolved into 2 mL of EtOAc and 4.0 N HCl in dioxane (1.0 mL, 4 mmol) was added. The reaction was allowed to stir overnight. The resulting precipitate was triturated with 3×5 mL of THF and concentrated on a rotary evaporator to dryness to give 43 mg of 6-(2-amino-1-hydroxy-ethyl)-N-benzyl-nicotinamide 2HCl.

Workup

  1. additionwas added
  2. customThe resulting precipitate was triturated with 3×5 mL of THF
  3. concentrationconcentrated on a rotary evaporator to dryness

Sources & evidence

ORD record
ord-cc0c0361f72d47efb02a5a761b907d74
Source dataset
uspto-grants-2006_10
Patent number
US07119102B2

Reaction notes

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