HCID 178519336, compound → HCID 178519335, compound

HRID 1243803Notes

Reaction equation

HRID 1243803 reaction equation
[C:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][C:14]([CH2:16][OH:17])=[CH:15][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1COCC1.O=[Mn]=O>[C:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][C:14]([CH:16]=[O:17])=[CH:15][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 178519336HCID 178519336, compound

Product 1

HCID 178519335HCID 178519335, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8028TetrahydrofuranSolvent

Procedure

(2-Phenyl-1H-benzoimidazol-5-yl)-methanol (783 mg, 3.49 mmol) was dissolved in 20 mL THF. Added MnO2 (3.035 g, 34.91 mmol) and stirred at RT for 1 hour. Filtered through celite and removed solvent in vacuo. Obtained 769 mg (99.1%) of 2-Phenyl-1H-benzoimidazole-5-carbaldehyde as a light yellow foam.

Workup

  1. filtrationFiltered through celite
  2. customremoved solvent in vacuo

Sources & evidence

ORD record
ord-fdc91b2e07b543a296cf12288a350966
Source dataset
uspto-grants-2006_10
Patent number
US07119102B2

Reaction notes

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