反应详情

温度

0 °C

A suspension of 3.35 gm (15.1 mmol) trimethylsulfoxonium iodide in 10 ml of THF at 0° C. under nitrogen was treated portionwise with 5.8 ml (14.6 mmol) of 2.5 M n-hexyllithium in heptane over 30 minutes. The mixture was stirred for 30 minutes at 0° C. and then treated with 1.0 gm (5.02 mmol) 6-Methoxy-1-methyl-1H-quinolin-2-one followed by heating under reflux for 1.5 hours. The reaction mixture was allowed to cool to ambient temperature before quenching with 35 ml of water followed by extraction into ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and evaporated to afford 1.1 gm of desired product. Mass spectrum APCI m/e 204 (p+1).

1. temperatureby heating
2. temperatureunder reflux for 1.5 hours
3. temperatureto cool to ambient temperature
4. custombefore quenching with 35 ml of water
5. extractionfollowed by extraction into ethyl acetate
6. washThe organic layer was washed with brine
7. dry with materialdried over sodium sulfate
8. customevaporated