Reserpine → HCID 10285937, compound

HRID 1244022Notes

Reaction equation

HRID 1244022 reaction equation
C1([C:4]2[CH:5]=[C:6]3[C:11](=[CH:12][C:13]=2[CH:14]=[O:15])[N:10]([CH3:16])[C:9](=[O:17])[CH2:8][CH2:7]3)CC1.[C:18]([O-])(=[O:20])[CH3:19].[NH4+].CO[C@@H]1[C@@H](C(OC)=O)[C@@H]2[C@@H](CN3[C@H](C2)C2NC4C=C(OC)C=CC=4C=2CC3)C[C@H]1OC(C1C=C(OC)C(OC)=C(OC)C=1)=O>C(#N)C>[CH2:18]([O:20][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[CH:14]=[O:15])[N:10]([CH3:16])[C:9](=[O:17])[CH2:8][CH2:7]2)[CH3:19]

Participants

5

Reactant 3

HCID 5770ReserpineHCID 517165Ammonium AcetateHCID 21931717HCID 21931717, compound

Product 1

HCID 10285937HCID 10285937, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared according to the procedure used for the preparation of 6-cyclopropyl-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carbaldehyde as a yellow solid. 1H NMR (400 MHz, CDCl3) δ 1.47 (3H, t, J=7.0 Hz), 2.65 (2H, m), 2.93 (2H, m), 3.36 (3H, s), 4.14 (2H, q, 7.1 Hz), 6.81 (1H, s), 7.42 (1H, s), 10.45 (1H, s). m/z (APCI+) 233.9 (M+1). HPLC (aqueous 200 Mm ammonium acetate buffer/acetonitrile gradient, 3.0 ml/min, Hewlett Packard ODS Hypersil 5 μM, 125×4 mm column), 4.167 min.

Sources & evidence

ORD record
ord-785686770fee47b1a1fe6279c095402b
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

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