HRID1244065

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1

HCID12362975

未命名化合物

HCID21931648

未命名化合物

PRODUCTS

生成物

结构：CC[C@H]1CC[C@H](N)[C@H](c2ccccc2)N1.O=C(O)[C@@](O)(C(=O)c1ccccc1)[C@@](O)(C(=O)O)C(=O)c1ccccc1

HCID131725987

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

(+/−)-6-Ethyl-2-phenyl-piperidin-3-ylamine (102 mg, 0.50 mmol) and (−) dibenzoyltartaric acid were dissolved by heating in 5 mL 2-propanol and 1 mL water. The resultant solid (26 mg, 25%) was determined to be 94% enriched in the (2S,3S,6S)-enantiomer.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-393455af80564cae91f8e03b78b8f3b6
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07119207B2
来源说明: uspto-grants-2006_10

反应 SMILES

[CH2:1]([CH:3]1[NH:8][CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]([NH2:15])[CH2:5][CH2:4]1)[CH3:2].[C:16]([C:24]([C:39]([OH:41])=[O:40])([OH:38])[C:25]([C:30](=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([OH:29])[C:26]([OH:28])=[O:27])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CC(O)C.O>[C:30]([C@@:25]([C:26]([OH:28])=[O:27])([OH:29])[C@@:24]([C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([OH:38])[C:39]([OH:41])=[O:40])(=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.[CH2:1]([C@@H:3]1[NH:8][C@@H:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C@@H:6]([NH2:15])[CH2:5][CH2:4]1)[CH3:2]