Benzoyl chloride → HCID 67063006, compound

Temperature

-30 °C

To a solution of ethyl 2-O-benzyl-6-deoxy-1-thio-β-D-galactopyranoside (1.03 g, 3.45 mmol) and DMAP (126 mg, 1.0 mmol) in 10 mL of dry CH2Cl2 at −30° C. was added Et3N (1.92 mL, 13.8 mmol). Benzoyl chloride (0.4 mL, 3.45 mmol) was added to this mixture in a dropwise fashion, and the stirred at −30° C. for 3 hr. The reaction was then quenched by the addition of MeOH (2 mL) and the mixture was gradually warmed to room temperature after which the resulting mixture was diluted with EtOAc (250 mL). The solution was washed with saturated NaHCO3 solution (2×20 mL), water (30 mL), dried over Na2SO4, concentrated and purified by flash chromatography (3:1 to 1:1 hexane/EtOAc) to give 1.12 g (80%) of the title product. [α]D=96.9° (c=1, CHCl3); 1H NMR (CDCl3) 8.09–8.03 (m, 2H), 7.56 (t, 1H, J=7.4 Hz), 7.49 (m, 2H), 7.22 (m, 2H), 7.18 (m, 3H), 5.28 (dd, 1H, J=3.0, 9.6 Hz), 4.87 (d, 1H, J=10.6 Hz), 4.67 (d, 1H, J=10.6 Hz), 4.56 (d, 1H, J=9.7 Hz), 4.12 (m, 1H), 3.85 (t, 1H, J=9.8 Hz), 3.80 (m, 1H), 2.81 (m, 2H), 1.93 (d, 1H, J=6.7 Hz), 1.36 (m, 6H); 13C NMR (CDCl3) 166.2, 138.0, 133.7, 130.2, 130.1, 128.9, 128.7, 128.6, 128.2, 85.7, 78.1, 77.6, 76.5, 76.0, 74.7, 70.9, 25.6, 16.9, 15.4; MS: calcd for C22H26O5SNa 425.1, found m/z 425.2 (M+Na).

1. customThe reaction was then quenched by the addition of MeOH (2 mL)
2. temperaturethe mixture was gradually warmed to room temperature after which the resulting mixture
3. additionwas diluted with EtOAc (250 mL)
4. washThe solution was washed with saturated NaHCO3 solution (2×20 mL), water (30 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated
7. custompurified by flash chromatography (3:1 to 1:1 hexane/EtOAc)

ORD record

ord-533492bf274a4994895cebec432c2ea3

Source dataset

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07122359B2