Piperidine → HCID 10406543, compound

HRID 1244267Notes

Reaction equation

HRID 1244267 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[C:4]([CH2:21][CH3:22])[CH:3]=1.[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH2:21]([C:4]1[CH:3]=[C:2]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[N:7]=[N:6][C:5]=1[CH2:8][N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=1)[CH3:22]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 9995922HCID 9995922, compound

Product 1

HCID 10406543HCID 10406543, compound

Conditions

Temperature
110 °C

Procedure

A mixture of 6-chloro-4-ethyl-3-[2-(3-fluoro-phenyl)-imidazol-1-ylmethyl]-pyridazine (55.3 mg, 0.17 mmol) and piperidine (5 mL) is heated at 110° C. for 5 hours. Excess piperidine is removed and the residue is purified by PTLC to give the title compound. LC-MS (M+1) 366.2 (retention time: 0.91 min).

Workup

  1. customExcess piperidine is removed
  2. customthe residue is purified by PTLC

Sources & evidence

ORD record
ord-3a58f62abcc14587963d3c3ce2163728
Source dataset
uspto-grants-2006_10
Patent number
US07122546B2

Reaction notes

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