反应详情

0.09 g 2-Methoxy-1-[2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4,5,7,8-tetrahydro-1H-imidazo[4,5-d]azepin-6-yl]-ethanone in 5 ml tetrahydrofurane were reacted with 0.2 ml lithiumaluminium hydride solution (1 M in tetrahydrofurane) over night at room temperature. 5 ml ethylacetate was added followed by 5 ml water at 0–5° C. Extraction with ethylacetate and chromatography on silicagel with dichloromethane/methanol 96:4 yielded 0.047 g (53%) 6-(2-methoxy-ethyl)-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-1,4,5,6,7,8-hexahydro-imidazo[4,5-d]azepine as yellow solid; MS (ISP): m/e=444 (M+H+).

1. extractionExtraction with ethylacetate and chromatography on silicagel with dichloromethane/methanol 96:4