Methyl iodide → 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboximidothioic acid methyl ester hydroiodide

HRID 1244371노트

반응식

HRID 1244371 반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([C:12](=[S:14])[NH2:13])[S:11][C:7]=2[C:6]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[I:21][CH3:22]>O1CCCC1>[IH:21].[CH3:22][S:14][C:12]([C:10]1[S:11][C:7]2[C:6]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=2[N:9]=1)=[NH:13]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 219192544-Methoxy-7-morpholin-4-yl-benzothiazole-2-carbothioic acid amide

생성물 1

HCID 691840724-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboximidothioic acid methyl ester hydroiodide수율 51%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

g 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carbothioic acid amide and 20.3 ml iodomethane in 100 ml tetrahydrofurane were stirred at room temperature for three days. The resulting precipitate was filtered to yield 0.74 g (51%) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboximidothioic acid methyl ester hydroiodide; M.p.: 169–171° C.; MS (ISP): m/e=324 (M+H+).

후처리

  1. filtrationThe resulting precipitate was filtered

출처 및 근거

ORD 기록
ord-4e438033d51b46e4b3cc65f3e1105296
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07122545B2

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