Nitroxyl → 2-Octanone
Reaction equation
[CH3:1][CH:2]([OH:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].N=O.[O-]Cl.[Na+]>>[CH3:1][C:2](=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]Participants
4
Procedure
In a flask 125 μl (0.8 mmol) of the 2-octanol, 3.2 mg (8 μmol) of the product from example 1 and 2.86 ml NaOCl-solution (0.35M; 1.0 mmol; pH 9.1 with KHCO3) were added; the mixture was maintained at room temperature under vigorously stirring. After one hour the crude organic layer was analyzed using GC: 100% of 2-octanone was obtained as desired product. The catalyst was recovered by filtration of the crude reaction mixture.
Sources & evidence
- ORD record
- ord-f07f712f6ce94ea8b5c4f1559606a505
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07122663B2
Reaction notes
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