HCID 178447847, compound → HCID 178447848, compound

HRID 1245270Notes

Reaction equation

HRID 1245270 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH2:14][CH2:13][CH:12]([C@H:15]2[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][CH3:23])[CH2:17][CH2:16]2)[CH2:11][CH:10]=1>[C].[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:10][CH2:11][CH:12]([C@H:15]2[CH2:20][CH2:19][C@H:18]([CH2:21][CH2:22][CH3:23])[CH2:17][CH2:16]2)[CH2:13][CH2:14]1

Participants

4

Reactant 1

HCID 178447847HCID 178447847, compound

Product 1

HCID 178447848HCID 178447848, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2,5-difluoro(4-(trans-4-propylcyclohexyl)cyclohexenyl)benzene (0.84 mmol), ethyl acetate (30 ml), and 5% palladium carbon (0.013 g) is stirred under an atmosphere of hydrogen. After ceasing the absorption of hydrogen, 5% palladium carbon is filtered off from the reaction mixture. The filtrate is concentrated under reduced pressure and purified by silica-gel chromatography, and further recrystallized to give the titled compound.

Workup

  1. customthe absorption of hydrogen, 5% palladium carbon
  2. filtrationis filtered off from the reaction mixture
  3. concentrationThe filtrate is concentrated under reduced pressure
  4. custompurified by silica-gel chromatography
  5. customfurther recrystallized

Sources & evidence

ORD record
ord-d4b2d31a8a664577b14059ca0efc453e
Source dataset
uspto-grants-2006_10
Patent number
US07125589B1

Reaction notes

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