Hydrochloric Acid → HCID 10366114, compound

HRID 1245330Notes

Reaction equation

HRID 1245330 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:23]=[CH:22][C:14]3[C:15]([C:18]([F:21])([F:20])[F:19])=[N:16][O:17][C:13]=3[C:12]=2[CH2:24][CH2:25][CH3:26])[CH2:5][CH2:4][N:3]1[CH:27]([CH3:32])[C:28]([O:30]C)=[O:29].[OH-].[Na+].Cl>CO>[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:23]=[CH:22][C:14]3[C:15]([C:18]([F:21])([F:20])[F:19])=[N:16][O:17][C:13]=3[C:12]=2[CH2:24][CH2:25][CH3:26])[CH2:5][CH2:4][N:3]1[CH:27]([CH3:32])[C:28]([OH:30])=[O:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21911002HCID 21911002, compound

Product 1

HCID 10366114HCID 10366114, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a MeOH solution (0.6 mL) of methyl 2-[2-oxo-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)imidazolidin-1-yl]propanoate as prepared in Example 40 (17.6 mg, 0.039 mmol), was added NaOH (0.6 mL, 0.154 mmol) and the mixture stirred at room temperature overnight. The reaction mixture was neutralized with 1N HCl and purified by preparative HPLC and the title compound was obtained.

Workup

  1. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-1582144999d345298acdad1fb0affe9d
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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