Sodium Cyanide → HCID 9795546, compound

HRID 1245414Notes

Reaction equation

HRID 1245414 reaction equation
[C-:1]#[N:2].[Na+].Cl[C:5]1[N:10]=[C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:8]=[C:7]([N:19]([CH3:21])[CH3:20])[N:6]=1>CN(C)C=O>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([NH:11][C:9]2[N:8]=[C:7]([N:19]([CH3:21])[CH3:20])[N:6]=[C:5]([C:1]#[N:2])[N:10]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 55124806HCID 55124806, compound

Product 1

HCID 9795546HCID 9795546, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

Sodium cyanide (0.138 g) was added to a solution of the product from step (ii) (0.4 g) in N,N-dimethylformamide (20 ml) and heated at 90° C. for 16 h. The mixture was partitioned between ethyl acetate and water, a solid formed which was filtered off and purified by RPHPLC 15–85% acetonitrile in aqueous trifluoroacetic acid. Yield 0.05 g

Workup

  1. customThe mixture was partitioned between ethyl acetate and water
  2. customa solid formed which
  3. filtrationwas filtered off
  4. custompurified by RPHPLC 15–85% acetonitrile in aqueous trifluoroacetic acid

Sources & evidence

ORD record
ord-92dbbf2663404732949a2e5f21741e80
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

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