反应详情

温度

110 °C

4-Chloroaniline (1.44 g) was added to a solution of the product from step (i) (0.88 g) and N,N-diisopropylethylamine (0.484 g) in 1,4-dioxane (15 ml) and isopropylalcohol (15 ml) and the mixture heated at 110° C. for 6 days. The mixture was partitioned between ethyl acetate and water, the organics dried (MgSO4), and evaporated under reduced pressure. The solid was triturated with ethyl acetate, filtered and the filtrate purified by chromatography on silica eluting with 3% ethyl acetate in toluene. Yield 0.28 g

1. customThe mixture was partitioned between ethyl acetate and water
2. dry with materialthe organics dried (MgSO4)
3. customevaporated under reduced pressure
4. customThe solid was triturated with ethyl acetate
5. filtrationfiltered
6. customthe filtrate purified by chromatography on silica eluting with 3% ethyl acetate in toluene