Piperazine → HCID 10043155, compound

HRID 1245424Notes

Reaction equation

HRID 1245424 reaction equation
Cl[C:2]1[C:7]([O:8][CH3:9])=[C:6]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:5]=[C:4]([C:18]#[N:19])[N:3]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>O1CCCC1>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][C:6]2[C:7]([O:8][CH3:9])=[C:2]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[N:3]=[C:4]([C:18]#[N:19])[N:5]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 21912465HCID 21912465, compound

Product 1

HCID 10043155HCID 10043155, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the product from step (v) (0.25 g) and piperazine (0.366 g) in tetrahydrofuran (8 ml) was heated at 60° C. for 6 h then the solvent removed under reduced pressure. The residue was purified by RPHPLC 15–75% acetonitrile in aqueous trifluoroacetic acid. Yield 0.139 g

Workup

  1. customthe solvent removed under reduced pressure
  2. customThe residue was purified by RPHPLC 15–75% acetonitrile in aqueous trifluoroacetic acid

Sources & evidence

ORD record
ord-1742a264e1264f09808c0f7f54b6a00e
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

Loading…