Hydrochloric Acid → HCID 131726000, compound

HRID 1245584Notes

Reaction equation

HRID 1245584 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:15]([CH2:23][CH3:24])=[N:16][N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=23)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>CO>[ClH:25].[CH2:23]([C:15]1[C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[C:18]2[CH2:19][CH2:20][CH2:21][CH2:22][N:17]2[N:16]=1)[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912764HCID 21912764, compound

Product 1

HCID 131726000HCID 131726000, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1-(tert-Butoxycarbonyl)-4-(2-ethyl-4,5,6,7 tetrahydropyrazolo[1,5-a]pyridin-3-yl)-piperidine (1.41 g, from Step F) in MeOH (15 mL) was added a saturated HCl solution in MeOH (15 mL) at 0° C. After stirring at rt for 3 h, the reaction mixture was concentrated to give the title compound as a foamy solid, which was used without further purification.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-6668b1a263234131996049af53fb89ad
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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