Piperidine → 4-(1-Ethyl-3-methoxy-4-methyl-1H-pyrazol-5-yl)piperidine

HRID 1245600Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([O:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.N1CCCCC1>>[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([O:21][CH3:22])=[N:17]1)[CH3:20]

Participants

Reactant 2

HCID 8082Piperidine

HCID 21912745HCID 21912745, compound

Product 1

HCID 219127714-(1-Ethyl-3-methoxy-4-methyl-1H-pyrazol-5-yl)piperidine

Procedure

The title compound was prepared from 1-tert-butoxycarbonyl-4-(1-ethyl-3-methoxy-4-methyl-(1H)-pyrazol-5-yl)piperidine (Step E) using a procedure analogous to that described for Piperidine 14, Step F. 1H-NMR (500 MHz) δ 1.33 (t, J=7.1, 3H), 1.70–1.73 (m, 2H), 1.86–1.96 (m, 5H), 2.67–2.72 (m, 3H), 3.19–3.21 (m, 2H), 3.89 (s, 3H), 3.99 (q, J=7.1, 2H).

Sources & evidence

ORD record: ord-ef3ce89c10c841fb9fe394575e071bdd
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125887B2

Reaction notes

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