HCID 21912733, compound → HCID 21912790, compound

HRID 1245602Notes

Reaction equation

HRID 1245602 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]([CH:20]([OH:22])[CH3:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>N1CCCCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]([C:20](=[O:22])[CH3:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 21912733HCID 21912733, compound

Product 1

HCID 21912790HCID 21912790, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

The title compound was prepared from ethyl 2-(R/S)-(1-tert-butoxycarbonyl-piperidin-4-yl)-3-(R/S)-hydroxy-butanoate (from Step A) using a procedure analogous to that described in Piperdine 8, Step D. 1H-NMR (500 MHz) δ 1.11–1.22 (m, 2H), 1.27 (t, J=7.0, 3H), 1.41 (s, 9H), 1.57–1.68 (m, 2H), 2.23 (s, 3H), 2.23–2.30 (m, 1H), 2.72 (br s, 2H), 3.27 (d, J=9.5, 1H), 4.09 (br s, 2H), 4.21 (q, J=7.0, 2H).

Sources & evidence

ORD record
ord-cd214a42809e4cafb1b80afe20435b7b
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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