Piperidine → HCID 21912702, compound

HRID 1245604Notes

Reaction equation

HRID 1245604 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:15](=[O:20])[NH:16][NH:17][C:18]=2[CH3:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].N1CCCC[CH2:22]1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:15]([O:20][CH3:22])=[N:16][NH:17][C:18]=2[CH3:19])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21912759HCID 21912759, compound

Product 1

HCID 21912702HCID 21912702, compound

Procedure

The title compound was prepared from 1-tert-butoxycarbonyl-4-(5-methyl-3-oxo-(1H)-pyrazol-4-yl)piperidine (Step C) using a procedure analogous to that described for Piperidine 15, Step D. RF: 0.34 (7:3 v/v hexanes/acetone); 1H-NMR (500 MHz) δ 1.47 (s, 9H), 1.57–1.59 (m, 2H), 1.75–1.83 (m, 2H), 2.16 (s, 3H), 2.44–2.50 (m, 1H), 2.70 (m, 2H), 3.86 (s, 3H), 4.17 (m, 2H); 13C-NMR (125 MHz) δ 55.8 (O—CH3).

Sources & evidence

ORD record
ord-9af2867a251a44fc8443d23fdb531328
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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