Piperidine → HCID 21912765, compound

HRID 1245605Notes

Reaction equation

HRID 1245605 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:15]([O:20][CH3:21])=[N:16][NH:17][C:18]=2[CH3:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].N1CCC[CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:15]([O:20][CH3:21])=[N:16][N:17]([CH2:23][CH3:24])[C:18]=2[CH3:19])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21912702HCID 21912702, compound

Product 1

HCID 21912765HCID 21912765, compound

Procedure

The title compound was prepared from 1-tert-butoxycarbonyl-4-(3-methoxy-5-methyl-(1H)-pyrazol-4-yl)piperidine (Step D) using a procedure analogous to that described for Piperidine 15, Step E. RF: 0.29 (9:1 v/v hexanes/acetone); 1H-NMR (500 MHz) δ 1.31 (t, J=7.3, 3H), 1.47 (s, 9H), 1.54–1.56 (m, 2H), 1.79–1.87 (m, 2H), 2.13 (s, 3H), 2.38–2.45 (m, 1H), 2.70 (m, 2H), 3.84 (s, 3H), 3.91 (q, J=7.3, 2H), 4.25 (m, 2H).

Sources & evidence

ORD record
ord-ffc4089994ca4715b2480068553a215c
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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