Dimethyl Sulfoxide → HCID 86760288, compound

Temperature

0 °C

A solution of 4.3 mL (49.8 mmol) of oxalyl chloride in 90 mL of CH2Cl2 at −78° C. was treated with 5.4 mL (75.7 mmol) of DMSO maintaining the temperature at less than −60° C. The resulting mixture was stirred cold for 5 min. A solution of 6.4 g (21.6 mmol) of 1-tert-butoxycarbonyl-3-(R)-(hydroxymethyl)-4-(S)-(3-fluoro)phenylpyrrolidine (from Step B) in 10 mL of CH2Cl2 was added maintaining the temperature at less than −60° C. The resulting mixture was stirred cold for 60 min. The mixture was treated with 30 mL (173.1 mmol) of N,N-diisopropylethylamine maintaining the temperature at less than −60° C. The reaction was warmed to 0° C., stirred for 20 min and quenched with 20 mL 0.5 N KHSO4. The mixture was partitioned between 250 mL of CH2Cl2 and 100 mL of H2O and the layers were separated. The aqueous layer was extracted with 250 mL of CH2Cl2. The combined organic phases were dried over MgSO4 and concentrated. Purification by Biotage Flash 75 using 75 L cartridge and 6.0 L of 9:1 v/v heptane/ethyl acetate as the eluant afforded the title compound: 1H NMR (500 MHz, CDCl3) δ 1.48 (s, 9H), 2.48 (1H), 3.17–3.89 (6H), 6.96–7.35 (4H), 9.67 (s, 1H).

1. temperaturemaintaining the temperature at less than −60° C
2. stirringThe resulting mixture was stirred cold for 60 min
3. stirringstirred for 20 min
4. customquenched with 20 mL 0.5 N KHSO4
5. customThe mixture was partitioned between 250 mL of CH2Cl2 and 100 mL of H2O
6. customthe layers were separated
7. extractionThe aqueous layer was extracted with 250 mL of CH2Cl2
8. dry with materialThe combined organic phases were dried over MgSO4
9. concentrationconcentrated
10. customPurification by Biotage Flash 75 using 75 L cartridge and 6.0 L of 9:1 v/v heptane/ethyl acetate as the eluant

ORD record

ord-9cb50286704c4424bb336ec88d5a3c0f

Source dataset

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07125887B2