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HRID1245738

反应详情

EQUATION

反应方程式

HRID 1245738 的结构方程式

REACTANTS

反应物

4
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccccc1N(C)C
HCID11869

N,N,2-Trimethylaniline

C9H13N

结构：CCC(CC)Nc1cc(C)nc(Cl)c1C(=O)O
HCID24806661

未命名化合物

PRODUCTS

生成物

1
结构：CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C(=O)O
HCID24806259

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cu]
催化剂HCID23978

Copper

Cu

PROCEDURE

实验过程

The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid and trimethylaniline in the presence of potassium carbonate and copper in DMF. The desired product was isolated by silica gel column chromatography using 5% methanol in chloroform as solvent to give a tan solid, mp. 130–135° C.

WORKUP

后处理

  1. customThe title compound was prepared