Water → HCID 21914306, compound

HRID 1245792Notes

Reaction equation

HRID 1245792 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[CH2:9]([S:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12])[CH3:10].C(N(C(C)C)CC)(C)C.O>CC(N(C)C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([N:17]2[CH2:16][CH2:15][N:14]([S:11]([CH2:9][CH3:10])(=[O:12])=[O:13])[CH2:19][CH2:18]2)=[N:3][CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 693532,5-DibromopyridineHCID 81531DiisopropylethylamineHCID 4152941-(Ethanesulfonyl)piperazine

Product 1

HCID 21914306HCID 21914306, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

2,5-Dibromopyridine (1 g) was heated in dimethylacetamide (2.5 ml) with ethanesulfonylpiperazine (0.752 g) and diisopropylethylamine (1.84 ml) at 120° C. for 18 h. After cooling, the reaction mixture was poured into water (30 ml) and the precipitated solid was collected by filtration. The product was purified by column chromatography eluting with dichloromethane (0.50 g).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. customThe product was purified by column chromatography
  4. washeluting with dichloromethane (0.50 g)

Sources & evidence

ORD record
ord-8013dc4400c24533acc4f001b14bb091
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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