Hydrochloric Acid → HCID 21914815, compound

HRID 1246452Notes

Reaction equation

HRID 1246452 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18]C(=O)OC(C)(C)C)=[CH:12][CH:11]=2)[N:9]=1)(=[O:3])[CH3:2].[ClH:26]>C(OCC)(=O)C>[ClH:26].[NH2:18][CH2:17][CH2:16][C:13]1[CH:12]=[CH:11][C:10]([C:8]2[N:9]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[S:6][CH:7]=2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595592HCID 86595592, compound

Product 1

HCID 21914815HCID 21914815, compoundYield 106%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

tert-Butyl (2-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}ethyl)carbamate (250 mg) was dissolved in ethyl acetate (4 mL) and 4 N hydrogen chloride in ethyl acetate (2 mL). The solvent was evaporated in vacuo. The solid was washed with ethyl acetate and ethyl ether to give N-{4-[4-(2-aminoethyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride (220 mg, 106%).

Workup

  1. customThe solvent was evaporated in vacuo
  2. washThe solid was washed with ethyl acetate and ethyl ether

Sources & evidence

ORD record
ord-ce6fc35df1aa4b01984c675f4aa459fc
Source dataset
uspto-grants-2006_10
Patent number
US07125901B2

Reaction notes

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