反应详情

To a solution of N-[4-(2-{4-[(diformylamino)methyl]phenyl}ethyl)-1,3-thiazol-2-yl]acetamide (56 mg) in methanol (0.5 ml) was added 4N hydrogen chloride in ethyl acetate (0.5 ml), and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo. The residue was separated between chloroform (5 ml) and saturated aqueous sodium hydrogen bicarbonate (5 ml), and the aqueous layer was extracted with chloroform (5 ml). The organic layer was dried over sodium sulfate and concentrated in vacuo to give N-(4-{2-[4-(aminomethyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide (50 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was separated between chloroform (5 ml) and saturated aqueous sodium hydrogen bicarbonate (5 ml)
3. extractionthe aqueous layer was extracted with chloroform (5 ml)
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated in vacuo