反应详情

(RS)-N-(4-Cyano-benzyl)-2-(2-fluoro-4-methoxy-phenyl)-2-methoxy-acetamide (example 15.2, 251 mg) was dissolved in methanol (7 ml). Hydroxylamine hydrochloride (212 mg) and triethylamine (618 mg) were added. The mixture was stirred for 19 h at rt. The solvent was evaporated. The residue was dissolved in methylene chloride, washed with water, dried and filtered. The solvent was evaporated to give (RS)-2-(2-fluoro-4-methoxy-phenyl)-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-2-methoxy-acetamide (269 mg) as an off-white foam. MS 362.2 ([M+H]+)

1. customThe solvent was evaporated
2. dissolutionThe residue was dissolved in methylene chloride
3. washwashed with water
4. customdried
5. filtrationfiltered
6. customThe solvent was evaporated