Hydrochloric Acid → HCID 21906685, compound

HRID 1247615Notes

Reaction equation

HRID 1247615 reaction equation
[C:1]12([CH2:11][NH:12][C:13]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([NH:21][CH2:22][CH2:23][CH2:24][NH:25]C(=O)OC(C)(C)C)[C:16]=3[Cl:33])=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[ClH:34]>CO.O1CCOCC1>[ClH:33].[ClH:34].[C:1]12([CH2:11][NH:12][C:13](=[O:14])[C:15]3[CH:20]=[CH:19][N:18]=[C:17]([NH:21][CH2:22][CH2:23][CH2:24][NH2:25])[C:16]=3[Cl:33])[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21906727HCID 21906727, compound

Product 1

HCID 21906685HCID 21906685, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 3-[(4-{[(1-adamantylmethyl)amino]carbonyl}-3-chloropyridin-2-yl)amino]propylcarbamate (0.41 g) Example 36(i)) in methanol (15 ml) was treated with a solution of HCl in 1,4-dioxane (4 ml) and the mixture was stirred at room temperature for 18 hrs. The solution was evaporated. Methanol was added and the solution was evaporated to give the title compound as a pale yellow solid.

Workup

  1. customThe solution was evaporated
  2. additionMethanol was added
  3. customthe solution was evaporated

Sources & evidence

ORD record
ord-92ea745668e34504bc5700266ae9c4e1
Source dataset
uspto-grants-2006_10
Patent number
US07129246B2

Reaction notes

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