Ethyl formate → Ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate

HRID 1247898Notes

Reaction equation

HRID 1247898 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[CH:15](OCC)=[O:16].[H-].[Na+]>COCCOC>[CH:15]([CH:9]([CH2:8][C:5]1[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=1)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:16]

Participants

5

Reactant 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 3018102Ethyl 3-(6-methyl-3-pyridyl)propionate

Product 1

HCID 3018359Ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

(b)(i) Ethyl 3-(6-methyl-3-pyridyl)propionate was formylated with ethyl formate and sodium hydride in 1,2-dimethoxyethane to give ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate m.p. 142°-144°.

Sources & evidence

ORD record
ord-83973b616a2d4dbc807aaa17cecf6474
Source dataset
uspto-grants-1985_06
Patent number
US04521418

Reaction notes

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