Hydrochloric Acid → HCID 178481953, compound

HRID 1247931Notes

Reaction equation

HRID 1247931 reaction equation
[CH3:1][N:2]1[C:7]([SH:8])=[N:6][C:5](=[O:9])[C:4]([OH:10])=[N:3]1.Cl.Cl[CH2:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1.C(=O)(O)[O-].[Na+].Cl>O>[CH3:1][N:2]1[C:7]([S:8][CH2:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[N:6][C:5](=[O:9])[C:4]([OH:10])=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 745704-(Chloromethyl)pyridinium chlorideHCID 516892Sodium BicarbonateHCID 178481952HCID 178481952, compound

Product 1

HCID 178481953HCID 178481953, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
45 °C

Procedure

A mixture of 2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine (15.91 g), 4-chloromethylpyridine hydrochloride (19.68 g) and sodium bicarbonate (33.6 g) in water (500 ml) was stirred for 2 hours at 45° C. The mixture was cooled to 10° C. and adjusted to pH 6.2 with 6N hydrochloric acid. The resulting precipitates were collected by filtration, washed with water and acetone, and dried to give 2-methyl-3-(4-pyridylmethylthio)-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine (17.2 g), mp. 219° to 222° C. (dec.).

Workup

  1. temperatureThe mixture was cooled to 10° C.
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. washwashed with water and acetone
  5. customdried

Sources & evidence

ORD record
ord-1b2af458ce2a4961b474a2d9c7133624
Source dataset
uspto-grants-1985_06
Patent number
US04521413

Reaction notes

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