3-Acetylpyridine → 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

HRID 1247958Notes

Reaction equation

HRID 1247958 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].C(O[CH:15](N(C)C)[N:16]([CH3:18])[CH3:17])(C)(C)C>O1CCCC1>[CH3:15][N:16]([CH3:18])[CH:17]=[CH:2][C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

4

Reactant 2

HCID 95893-AcetylpyridineHCID 79885tert-Butoxy bis(dimethylamino)methane

Product 1

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 0.10 mole of 3-acetylpyridine in 100 ml of tetrahydrofuran was added 0.10 mole of tert.-butoxy-bis-(dimethylamino)methane. The mixture was stirred for 24 hours and the solvent removed, giving 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one.

Workup

  1. customthe solvent removed

Sources & evidence

ORD record
ord-66a7bcd24824440ba61d4ed7dbafb609
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Reaction notes

Loading…