反应详情

温度

0 °C

A 29 g portion of N-(3-acetylphenyl)-4-methylbenzenesulfonamide was dissolved in 250 ml of dimethylformamide with stirring. This mixture was treated with 6.5 g of sodium methoxide and stirred for 30 minutes, then 20 g of ethyl iodide was added. This mixture was stirred at room temperature for one hour, then at reflux for 5 hours. The dimethylformamide was removed in vacuo, the residue shaken with 150 ml of water, the mixture adjusted to pH 4 with 10N sodium hydroxide and then cooled to 0° C. The precipitate was collected, washed twice with water and then air dried, giving 31.5 g of N-(3-acetylphenyl)-N-ethyl-4-methylbenzenesulfonamide.

1. stirringstirred for 30 minutes
2. stirringThis mixture was stirred at room temperature for one hour
3. temperatureat reflux for 5 hours
4. customThe dimethylformamide was removed in vacuo
5. stirringthe residue shaken with 150 ml of water
6. customThe precipitate was collected
7. washwashed twice with water
8. customair dried