HCID 70489765, compound → HCID 13472332, compound

HRID 1248052Notes

Reaction equation

HRID 1248052 reaction equation
Cl.C([O:4][C:5](=[O:18])[C@H:6]([CH3:17])[NH:7][CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)C>Cl>[CH:8]1([NH:7][C@H:6]([C:5]([OH:18])=[O:4])[CH3:17])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 1

HCID 70489765HCID 70489765, compound

Product 1

HCID 13472332HCID 13472332, compoundYield 84.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-(1-Indanyl)alanine ethyl ester hydrochloride (9.0 g) is dissolved in 100 ml of 5N hydrochloric acid, and the mixture is refluxed for 3 hours. The reaction mixture is concentrated to dryness under reduced pressure, 10 ml of water is added to the residue, and the mixture is neutralized with aqueous ammonia. The resulting crystalline precipitates are collected by filtration, washed with water, and dried, to give 5.8 g of N-(1-indanyl)alanine as colorless scales. Melting point: 248°-250° C.

Workup

  1. temperaturethe mixture is refluxed for 3 hours
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure, 10 ml of water
  3. additionis added to the residue
  4. customThe resulting crystalline precipitates
  5. filtrationare collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-1f6725cf26a64fc38ebe2c11db0f5890
Source dataset
uspto-grants-1985_06
Patent number
US04521607

Reaction notes

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