Acetic Acid → HCID 20279418, compound

HRID 1248355Notes

Reaction equation

HRID 1248355 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[C:4]([C:6]1[C:16]([OH:17])=[CH:15][C:9]2[C:10]([C:12](N)=[O:13])=[CH:11][C:8]=2[CH:7]=1)=[O:5].C(O)(=[O:25])C>Cl>[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[C:4]([C:6]1[C:16]([OH:17])=[CH:15][C:9]2[C:10]([C:12]([OH:25])=[O:13])=[CH:11][C:8]=2[CH:7]=1)=[O:5]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 20279438HCID 20279438, compound

Product 1

HCID 20279418HCID 20279418, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2 g of 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxamide in 20 ml of acetic acid and 20 ml of concentrated hydrochloric acid are stirred for 4 hours at 95°-100°. The mixture is left to cool, filtered with suction, washed with water and recrystallised from trichloromethane/hexane. 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid is obtained having a melting point of 202°-203°.

Workup

  1. waitThe mixture is left
  2. temperatureto cool
  3. filtrationfiltered with suction
  4. washwashed with water
  5. customrecrystallised from trichloromethane/hexane

Sources & evidence

ORD record
ord-692e6cbdbef249c1a87fbcea93429dc5
Source dataset
uspto-grants-1985_06
Patent number
US04523030

Reaction notes

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