Dimethylformamide → HCID 53714737, compound

HRID 1248358Notes

Reaction equation

HRID 1248358 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[C:4]([C:6]1[C:16]([OH:17])=[CH:15][C:9]2[C:10]([C:12](O)=[O:13])=[CH:11][C:8]=2[CH:7]=1)=[O:5].CN(C)C=O.S(Cl)([Cl:30])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[C:4]([C:6]1[C:16]([OH:17])=[CH:15][C:9]2[C:10]([C:12]([Cl:30])=[O:13])=[CH:11][C:8]=2[CH:7]=1)=[O:5]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 20279418HCID 20279418, compound

Product 1

HCID 53714737HCID 53714737, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.37 g of 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid are suspended in 100 ml of toluene; 0.1 ml of dimethylformamide and 1.64 g of thionyl chloride are added and the whole is heated to 80°, stirred for 2 hours at 80°-90° and concentrated to dryness by evaporation under reduced pressure. 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid chloride is obtained which can be used without being further treated.

Workup

  1. temperaturethe whole is heated to 80°
  2. concentrationconcentrated to dryness by evaporation under reduced pressure

Sources & evidence

ORD record
ord-275e2c0a88134af8a6d3cdab07684f17
Source dataset
uspto-grants-1985_06
Patent number
US04523030

Reaction notes

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