反应详情

Sodium hydride (7.15 g) was added portion-wise to a stirred solution of 3-hydroxypyridine (19 g) in dry dimethylsulphoxide (100 ml) during 1 hr. Ethyl bromoacetate (33.4. g) was added during 1 h. and water (250 ml) slowly added. The solution was extracted with chloroform (3×150 ml) and the combined extracts washed with 2 N sodium carbonate (75 ml) and dried (Na2SO4). Evaporation of the solvent gave a liquid which was distilled (120°-130°/0.1 mm) to yield the title compound (8.7 g).

1. extractionThe solution was extracted with chloroform (3×150 ml)
2. washthe combined extracts washed with 2 N sodium carbonate (75 ml)
3. dry with materialdried (Na2SO4)
4. customEvaporation of the solvent
5. customgave a liquid which
6. distillationwas distilled (120°-130°/0.1 mm)