Dimethylformamide dimethyl acetal → HCID 54179722, compound

HRID 1248800Notes

Reaction equation

HRID 1248800 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:14])[CH2:12][CH3:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:17][N:18]([CH3:20])[CH:19]=[CH:2][C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:14])[CH2:12][CH3:13])[CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 903063N-(3-acetylphenyl)propanamide

Product 1

HCID 54179722HCID 54179722, compound

Procedure

A 20 g portion of N-(3-acetylphenyl)propanamide in 50 ml of dimethylformamide dimethylacetal was refluxed for 8 hours, then evaporated. The residue was taken up in 200 ml of dichloromethane, passed through hydrous magnesium silicate, diluted with hexane and concentrated, giving 21.17 g of the desired compound.

Workup

  1. customevaporated
  2. additiondiluted with hexane
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-647e0318f20d4f7a9fbc814b692fda3a
Source dataset
uspto-grants-1986_12
Patent number
US04626538

Reaction notes

Loading…