反应详情

A solution of 148.6 g. of 6-methoxy-1,2,3,4-tetrahydroquinoline and 58 g. of propionaldehyde in 275 ml. of ethanol was hydrogenated at 60 psi over 15 g. of 15% palladium on carbon at room temperature for 2 hours and then at 50° C. overnight. The catalyst was removed by filtration and the filtrate concentrated to give a brown oil which was distilled to give 100.5 g. of 6-methoxy-1-n-propyl-1,2,3,4-tetrahydroquinoline (54% yield) as an oil boiling in the range 115°-128° C. at 0.02 Torr.

1. customat 50° C.
2. customovernight
3. customThe catalyst was removed by filtration
4. concentrationthe filtrate concentrated
5. customto give a brown oil which
6. distillationwas distilled
7. customto give 100.5 g