Hydrochloric Acid → 1-(4-Methylphenyl)ethanone 2,4,6-triisopropylbenzenesulphonylhydrazone

HRID 1248990Notes

Reaction equation

HRID 1248990 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][CH:3]=1.Cl.[CH:12]([C:15]1[CH:20]=[C:19]([CH:21]([CH3:23])[CH3:22])[CH:18]=[C:17]([CH:24]([CH3:26])[CH3:25])[C:16]=1[S:27]([NH:30][NH2:31])(=[O:29])=[O:28])([CH3:14])[CH3:13]>CO>[CH:24]([C:17]1[CH:18]=[C:19]([CH:21]([CH3:23])[CH3:22])[CH:20]=[C:15]([CH:12]([CH3:13])[CH3:14])[C:16]=1[S:27]([NH:30][N:31]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1)[CH3:9])(=[O:28])=[O:29])([CH3:25])[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8500p-METHYLACETOPHENONEHCID 3593332,4,6-Triisopropylbenzenesulphonohydrazide

Product 1

HCID 867411431-(4-Methylphenyl)ethanone 2,4,6-triisopropylbenzenesulphonylhydrazoneYield 86.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(4-Methylphenyl)ethanone (2.28 g) and concentrated hydrochloric acid (1 ml) were added to a stirred solution of 2,4,6-triisopropyl benzenesulphonylhydrazine (5 g) in methanol (20 ml). The resulting mixture was stirred until a dense white precipitate formed. The precipitate was removed by filtration and washed with cold methanol to yield 1-(4-methylphenyl)ethanone 2,4,6-triisopropylbenzenesulphonylhydrazone (6 g) as a fine white crystalline solid.

Workup

  1. customformed
  2. customThe precipitate was removed by filtration
  3. washwashed with cold methanol

Sources & evidence

ORD record
ord-526cbbf06b0e49e1ba1c2ceac8c144c7
Source dataset
uspto-grants-1986_12
Patent number
US04628104

Reaction notes

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