Methyl iodide → HCID 13561992, compound

HRID 1249080Notes

Reaction equation

HRID 1249080 reaction equation
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][CH:3]([C:14]([NH2:16])=[O:15])[NH:2]1.C(N(CC)CC)C.[C:24](=[S:26])=[S:25].[CH3:27]I>C(O)C>[CH3:27][S:25][C:24]([N:2]1[CH:3]([C:14]([NH2:16])=[O:15])[CH2:4][C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:12][C:13]=2[CH2:1]1)=[S:26]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 11085189HCID 11085189, compound

Product 1

HCID 13561992HCID 13561992, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as described in Example 53, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxamide (0.71 g), triethylamine (0.46 ml), carbon disulfide (0.22 ml), 70% ethanol (20 ml) and methyl iodide (0.22 ml) are reacted and treated. The product is crystallized from ethyl acetate to give the title compound (0.414 g), m.p. 224°-225° C. (decomp.).

Workup

  1. customare reacted
  2. additiontreated
  3. customThe product is crystallized from ethyl acetate

Sources & evidence

ORD record
ord-3655041b0fee4fbfb804794b9e3c85f5
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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